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also known as carbolic acid, is an aromaticorganic compound with the
molecular formula C6H5OH. It is a white crystallinesolidthat is volatile.
The molecule consists of a phenyl group(−C6H5)bonded to a hydroxyl group
(−OH). It is mildly acidicand requires careful handling due to its
propensity to cause chemicalburns.
Phenol was first extracted from coal tar,but today is produced on a large scale (about 7 billion kg/year) from petroleum.It is an important industrial commodity as a precursor to many materials and usefulcompounds.It is primarily used to synthesize plasticsand related materials. Phenol and its chemical derivatives are essential for productionof polycarbonates,epoxies,Bakelite,nylon,detergents,herbicidessuch as phenoxy herbicides, and numerous pharmaceutical drugs.
Although similar to alcohols, phenols have unique properties. Unlike alcohols,where the hydroxyl group is bound to a saturated carbon atom,phenols have thehydroxyl group attached to an unsaturated aromatic (alternating double and single bond)hydrocarbonbenzene ring. Phenolshave greater acidity than alcohols because of the stabilization of the conjugatebase through resonance in the aromatic ring.
Appearance Crystalline solid,no precipitate,no turbidity
Solubilit Test(1:20 absorbance)
Superior product. Comply with the USP31 Standard.
200kg/drum, 80drum/20ft container=16mts/20ft container
Because of phenol's commercialimportance, many methods have been developed for its production. The dominantcurrent route, accounting for 95% of production (2003), is the cumeneprocess, which involves the partial oxidation of cumene(isopropylbenzene) via the Hock rearrangement:
C6H5CH(CH3)2 + O2 → C6H5OH + (CH3)2CO
Acetoneis produced as a by-product. Compared to most other processes, the cumeneprocess uses relatively mild synthesis conditions, and relatively inexpensiveraw materials. However, to operate economically, there must be demand for bothphenol, and the acetone by-product.
An early commercial route,developed by Bayerand Monsantoin the early 1900s, begins with the reaction of a strong base with benzenesulfonate:
C6H5SO3H + 2 NaOH → C6H5OH + Na2SO3 + H2O
Other methods under considerationinvolve:
hydrolysis of chlorobenzene, using base (Dow's Process) or steam (Raschig–Hooker process):
C6H5Cl + H2O → C6H5OH + HCl
Direct oxidation of benzene with nitrous oxide, a potentially "green" process:
C6H6 + N2O → C6H5OH + N2
oxidation of toluene, as developed by Dow Chemical:
C6H5CH3 + 2 O2 → C6H5OH + CO2 + H2O
In the Lummus Process, theoxidation of toluene to benzoic acid is conducted separately.
Phenol is also a recoverablebyproduct of coalpyrolysis.
The major uses of phenol,consuming two thirds of its production, involve its conversion to precursorsfor plastics. Condensation with acetone gives bisphenol-A,a key precursor to polycarbonates and epoxide resins.Condensation of phenol, alkylphenols, or diphenols with formaldehydegives phenolic resins, a famous example of which is Bakelite.Partial hydrogenation of phenol gives cyclohexanone,a precursor to nylon.Nonionic detergentsare produced by alkylation of phenol to give the alkylphenols,e.g., nonylphenol,which are then subjected to ethoxylation.
Phenol is also a versatileprecursor to a large collection of drugs, most notably aspirinbut also many herbicides and pharmaceutical drugs. Phenol is also used as anoral anesthetic/analgesic in products such as Chlorasepticor other brand name and generic equivalents, commonly used to temporarily treatpharyngitis.
Phenol is a component in liquid/liquid phenol–chloroform extraction techniqueused in molecular biology for obtaining nucleic acidsfrom tissues or cell culture samples. Depending on the pH of the solutioneither DNA or RNA can be extracted.